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Chicken Bubble Biscuit Bake Casserole

Chicken Bubble Biscuit Bake Casserole for Cozy Family Nights

This Chicken Bubble Biscuit Bake Casserole blends tender chicken, fluffy biscuits, and a creamy sauce for a comforting dish. Perfect for busy weeknight dinners.
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Prep Time 10 minutes
Cook Time 30 minutes
Total Time 40 minutes
Servings: 6 servings
Course: Dinner
Cuisine: American
Calories: 450
Ingredients Equipment Method Nutrition Notes

Ingredients
  

For the Filling
  • 2 cups Cooked Chicken Rotisserie chicken works great for quick prep.
  • 1 can Cream of Chicken Soup Substitute with cream of mushroom or cream of celery for a twist.
  • 1 cup Sour Cream Greek yogurt can replace sour cream for a lighter option.
  • 1/2 cup Milk Use any milk of choice.
  • 2 cups Frozen Mixed Vegetables Can substitute with fresh vegetables like peas or broccoli.
  • 1 teaspoon Garlic Powder Fresh garlic can be used for a stronger taste.
  • 1 teaspoon Onion Powder Yellow onion can be sautéed and added for a different flavor profile.
  • to taste Salt & Pepper Adjust according to taste.
For the Biscuit Topping
  • 1 can Refrigerated Biscuit Dough Cut into quarters to ensure even baking.
  • 1 cup Shredded Cheese Cheddar is traditional, or use mozzarella for a milder taste.
  • 2 tablespoons Melted Butter Optional for brushing on top for added richness.

Equipment

  • 9x13-inch baking dish
  • Mixing bowl
  • Oven

Method
 

Step‑by‑Step Instructions
  1. Preheat your oven to 350°F (175°C). Grease a 9x13-inch baking dish with cooking spray or butter.
  2. In a large bowl, combine chicken, cream of chicken soup, sour cream, milk, frozen mixed vegetables, garlic powder, onion powder, salt, and pepper. Stir until smooth and creamy.
  3. Gently fold in quartered biscuit pieces into the filling mixture, ensuring each is coated.
  4. Pour the mixture into the greased baking dish and spread evenly. Sprinkle shredded cheese on top.
  5. Cover with aluminum foil and bake for 20 minutes. Then remove the foil and bake for another 10-15 minutes until biscuits are puffed and golden.
  6. Optional: Brush the baked casserole with melted butter for extra richness. Allow cooling slightly before serving.

Nutrition

Serving: 1servingCalories: 450kcalCarbohydrates: 40gProtein: 25gFat: 25gSaturated Fat: 12gPolyunsaturated Fat: 2gMonounsaturated Fat: 5gCholesterol: 75mgSodium: 800mgPotassium: 400mgFiber: 3gSugar: 2gVitamin A: 500IUVitamin C: 10mgCalcium: 250mgIron: 2mg

Notes

This casserole can be assembled a day in advance and refrigerated. Leftovers can be stored in an airtight container for up to 4 days.

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