In a mixing bowl, combine the ground beef with Cajun seasoning, garlic powder, onion powder, salt, and pepper. Gently mix with your hands until incorporated.

Divide the meat mixture into four equal portions and shape each into a patty about ¾ inch thick, creating an indentation in the center.

Preheat the grill or skillet over medium-high heat for about 5 minutes, and lightly grease the surface.

Place the patties on the hot grill or skillet and cook for 4-5 minutes. Avoid moving them to allow a crust to form.

Flip the patties gently and cook for another 3-4 minutes. Add a slice of cheese on each patty during the last minute of cooking.

Toast the burger buns cut-side down on the grill or in a skillet for about 1-2 minutes until golden brown.

Spread condiments on the bottom half of each toasted bun, layer on the cooked patty with melted cheese, and add toppings before capping with the top bun.